CD11b Monoclonal / Brilliant Ultraviolet 395 / ICRF44

Product Details
Supplier Thermo Fisher Scientific
Catalog #: 363-0118-42 (View supplier product page)
Size 100 Tests
Price $395.00
Antigen CD11b
Clone ICRF44
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Ultraviolet 395
Target Species Baboon, Chimpanzee, Cynomolgus macaque, Human, Rhesus macaque
Applications FC
Description CD11b Monoclonal Antibody (ICRF44), Brilliant Ultra Violet 395, eBioscience
About CD11b and Brilliant Ultraviolet 395
CD11b This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Brilliant Ultraviolet 395 Brilliant™ UltraViolet 395 (BUV395) is a UV-emitting base polymer dye that can be excited by the 355 nm UV laser and collected using a 379/28 bandpass filter. BUV395 has an excitation peak at 348 nm and an emission peak at 395. BUV395's fairly unique excitation and emission spectrum causes relatively little spillover into other common detectors and conflicts with very few other commonly used fluorophores. An alternative to BUV395 for flow cytometry is StarBright UltraViolet 400. This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. These dyes were optimized for use with multicolor flow cytometry. BUV395 forms the backbone of the family, as all other members are tandems that use it as the acceptor, thus making them excitable by the same 355 nm UV laser.
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Brilliant Ultraviolet 395 Excitation and Emission Spectra