ErbB2 / RealBlue 613 / NEU 24.7

Product Details
Supplier BD Biosciences
Catalog #: 758485 (View supplier product page)
Size 50 μg
Price $410.00
Antigen ErbB2
Clone NEU 24.7
Host Mouse
Isotype IgG1
Conjugate RealBlue 613
Target Species Human
Applications FC
Description Hu CD340 RB613 NEU 24.7 50ug
About ErbB2 and RealBlue 613
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
RealBlue 613 RealBlue™ 613 (RB613) from BD Biosciences is a very bright alternative to PE-CF®594 and PE-Dazzle® 594 tandem fluorophores and has the advantage of discrete excitation off of the 488nm laser without much cross-beam excitation by the 532 or 561nm lasers. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications. RB613 will peak in the same emission channel at 613nm as PE-CF®594 and PE-Dazzle® 594 tandem fluorophores.
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RealBlue 613 Excitation and Emission Spectra