CD86 RayBright Red 780 (GL-1, Rat) - Reactivity: Mouse

About CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

About RayBright Red 780
RayBright Red 780 is a red-emitting tandem fluorophore of APC, excited by the 633 nm red laser and transfers energy to deeper red-emitting acceptor molecule which emits light that can be captured with a 780/60 nm bandpass filter. APC-eF780 has an excitation peak at 645 nm and an emission peak at 767 nm, and is spectrally similar to APC-eFluor 780 (ThermoFisher), APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-Vio®770 (Miltenyi Biotec) and APC-Fire™ 750 (BioLegend).