CD25 / RayBright Red 647 / 7G7B6

Product Details
Supplier RayBiotech
Catalog #: 136-24008-025 (View supplier product page)
Size 25 Tests
Price $105.00
Antigen CD25
Clone 7G7B6
Host Mouse
Isotype IgG2a κ
Conjugate RayBright Red 647
Target Species Human
Applications FC
Description RayBright® Red 647 Human CD25 Antibody [clone: 7G7B6], monoclonal Mouse IgG2a kappa. Validated for flow cytometry.
About CD25 and RayBright Red 647
CD25 The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
RayBright Red 647 RayBright Red 647 from RayBiotech has an excitation peak at 646 nm and an emission peak at 660 nm. It is similar in structure, size and application to Alexa Fluor 647 (ThermoFisher) and CF647 (Biotium). It is useful in fluorescence microscopy and flow cytometry applications.
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RayBright Red 647 Excitation and Emission Spectra