MSR1 / Biotin / 2F8 (recombinant version)
MSR1 / Biotin / 2F8 (recombinant version)
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab00163-8.1-biotin (View supplier product page) | |
| Size | 100 μg | |
| Price | ||
| Antigen | MSR1 | |
| Clone | 2F8 (recombinant version) | |
| Host | Rat | |
| Isotype | IgG2b | |
| Conjugate | Biotin | |
| Target Species | Mouse | |
| Applications | IP, WB, IHC | |
| Description | Anti-CD204 [2F8 (recombinant version)] |
About MSR1 and Biotin
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
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Citations
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