ABCG2 / Biotin / 5D3
ABCG2 / Biotin / 5D3
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab02927-3.0-biotin (View supplier product page) | |
| Size | 200 μg | |
| Price | ||
| Antigen | ABCG2 | |
| Clone | 5D3 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | Biotin | |
| Target Species | Human | |
| Applications | FC, IHC, IF | |
| Description | Anti-ABCG2 [5D3] |
About ABCG2 and Biotin
| ABCG2 | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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Citations
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