FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab00802-13.12-fluoroprobes647h (View supplier product page)
	Size	200 μg
	Price
	Antigen	CD95
	Clone	R-125224
	Host	Human
	Isotype	IgG4
	Conjugate	FluoroProbes647h
	Target Species	Human
	Applications	Activation, Bioimaging, ELISA, FC
	Description	Anti-Fas [R-125224]

	CD95	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
	FluoroProbes647h	FluoProbes 647H from Abcam has an excitation peak at 650 nm and an emission peak at 672 nm. It can be used in flow cytometry and fluorescence microscopy.

	Additional Sources

CD95 / FluoroProbes647h / R-125224