PCNA / Biotin / SPM350

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34767B (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen PCNA
Clone SPM350
Host Mouse
Isotype IgG2a κ
Conjugate Biotin
Target Species Chicken, Drosophila, Human, Mouse, Porcine, Primate, Rat, Yeast, Zebrafish
Applications FC, IHC-Fr, WB, IHC-P, ICC/IF, ELISA, IP, IHC
Description Recognizes a non-histone protein of 36kDa, which is identified as proliferating cell nuclear antigen (PCNA). It is also known as cyclin or polymerase delta auxiliary protein. Elevated expression of PCNA/cyclin has been shown in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. This MAb is excellent for multiple applications.
About PCNA and Biotin
PCNA The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
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Biotin Excitation and Emission Spectra