Fibronectin / Biotin / SPM246

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34749B (View supplier product page)
Size 0.1 ml
Price $569.00
Antigen Fibronectin
Clone SPM246
Host Mouse
Isotype IgG1 κ
Conjugate Biotin
Target Species Human, Mouse, Porcine, Rat
Applications FC, IHC-Fr, WB, IHC-P, ICC/IF, ELISA, IP, IHC
Description Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix, and blood. This MAb reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this MAb localizes to tumor vessels where it binds to the underlying basement. Epitope recognized by this antibody is not accessible in normal tissues to the circulating MAb indicating that it can be used to specifically target tumor vessels in vivo. TV-1 is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or MAbs.
About Fibronectin and Biotin
Fibronectin This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Biotin Excitation and Emission Spectra