FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab01711-10.0-fluorescein (View supplier product page)
	Size	200 μg
	Price
	Antigen	PRDM9
	Clone	RAB-C370
	Host	Human
	Isotype	IgG1
	Conjugate	Fluorescein
	Target Species	Human
	Applications	ELISA, IF, IP-MS, ChIP
	Description	Anti-PRDM9 [RAB-C370]

	PRDM9	The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
	Fluorescein	Fluorescein is an organic fluorophore first synthesized by Aldolf Bayer in 1871. FITC, an amine-reactive derivative, is also a commonly used name for this dye. It has an excitation peak at 494 nm and an emission peak at 512 nm.

	Additional Sources

PRDM9 / Fluorescein / RAB-C370