FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab01617-23.0-fluorescein (View supplier product page)
	Size	200 μg
	Price
	Antigen	CD40
	Clone	2C5
	Host	Rabbit
	Isotype	IgG
	Conjugate	Fluorescein
	Target Species	Chicken
	Applications	Agonist Activity, Activation, FC, IF
	Description	Anti-CD40 [2C5]

	CD40	This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
	Fluorescein	Fluorescein is an organic fluorophore first synthesized by Aldolf Bayer in 1871. FITC, an amine-reactive derivative, is also a commonly used name for this dye. It has an excitation peak at 494 nm and an emission peak at 512 nm.

	Additional Sources

CD40 / Fluorescein / 2C5