FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab00163-8.1-fluorescein (View supplier product page)
	Size	100 μg
	Price
	Antigen	MSR1
	Clone	2F8 (recombinant version)
	Host	Rat
	Isotype	IgG2b
	Conjugate	Fluorescein
	Target Species	Mouse
	Applications	IP, WB, IHC
	Description	Anti-CD204 [2F8 (recombinant version)]

	MSR1	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
	Fluorescein	Fluorescein is an organic fluorophore first synthesized by Aldolf Bayer in 1871. FITC, an amine-reactive derivative, is also a commonly used name for this dye. It has an excitation peak at 494 nm and an emission peak at 512 nm.

	Additional Sources

MSR1 / Fluorescein / 2F8 (recombinant version)