CD268 / Fluorescein / V3-46s
CD268 / Fluorescein / V3-46s
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab02649-10.3-fluorescein (View supplier product page) | |
| Size | 200 μg | |
| Price | ||
| Antigen | CD268 | |
| Clone | V3-46s | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | Fluorescein | |
| Target Species | Human, Mouse | |
| Applications | ELISA, Block/Neutralize | |
| Description | Anti-BR3 [V3-46s] |
About CD268 and Fluorescein
| CD268 | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| Fluorescein | Fluorescein is an organic fluorophore first synthesized by Aldolf Bayer in 1871. FITC, an amine-reactive derivative, is also a commonly used name for this dye. It has an excitation peak at 494 nm and an emission peak at 512 nm. |
Citations
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