CD59 / Streptavidin / 193-27
CD59 / Streptavidin / 193-27
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab01543-10.3-streptavidin (View supplier product page) | |
| Size | 200 μg | |
| Price | ||
| Antigen | CD59 | |
| Clone | 193-27 | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | Streptavidin | |
| Target Species | Human | |
| Applications | FC, IHC, IF | |
| Description | Anti-CD59 [193-27] |
About CD59 and Streptavidin
| CD59 | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
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Citations
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