FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab00142-2.0-pe/cy7 (View supplier product page)
	Size	200 μg
	Price
	Antigen	p53
	Clone	PAb421
	Host	Mouse
	Isotype	IgG2a
	Conjugate	PE-Cy7
	Target Species	Human, Monkey, Mouse, Rabbit, Rat
	Applications	ELISA, IF, IHC-Fr, IHC-P, In Vivo, IP, WB
	Description	Anti-p53 [PAb421]

	p53	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
	PE-Cy7	PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek).

	Additional Sources

p53 / PE-Cy7 / PAb421