FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab03655-10.3-pe/cy7 (View supplier product page)
	Size	100 μg
	Price
	Antigen	IL-12/IL-23 (p40)
	Clone	Antibody 80
	Host	Human
	Isotype	IgG1
	Conjugate	PE-Cy7
	Target Species	Human
	Applications	Inhibition, Block/Neutralize, ELISA, Functional
	Description	Anti-IL-12p40 [Antibody 80]

	IL-12/IL-23 (p40)	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
	PE-Cy7	PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek).

	Additional Sources

IL-12/IL-23 (p40) / PE-Cy7 / Antibody 80