FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-109-308 (View supplier product page)
	Size	30 tests in 300 µL
	Price	$145.00
	Antigen	PKC theta
	Clone	REA588
	Host	Human
	Isotype	IgG1
	Conjugate	APC
	Target Species	Human
	Applications	FC
	Description	Clone REA588 recognizes the human PKCθ antigen, which is a member of the protein kinase C (PKC) family of homologous serine/threonine protein kinases that phosphorylate the OH group of serine or threonine. PKCs play a role in the carcinogenesis and maintenance of malignant phenotype. PKCθ transcripts are expressed in hematopoietic tissues and cell lines, including T cells and thymocytes. \| Additional information: Clone REA588 displays negligible binding to Fc receptors.

	PKC theta	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$145.00
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PKC theta Monoclonal / APC / REA588