FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-109-225 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$395.00
	Antigen	CD299
	Clone	REA587
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Bright FITC
	Target Species	Human
	Applications	FC
	Description	Clone REA587 recognizes the human CD299 (L-SIGN) antigen, a type II integral membrane protein, also known as C-type lectin domain family 4 member M (CLEC4M) or liver/lymph node-specific ICAM-3-grabbing non-integrin. CD299 is expressed by sinusoidal endothelial cells in lymph nodes and is found in placental endothelium but not in macrophages. It is also expressed in type II alveolar cells and lung endothelial cells. CD299 has a high affinity for both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. \| Additional information: Clone REA587 displays negligible binding to Fc receptors.

	CD299	This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]
	Vio Bright FITC	Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.

$395.00
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CD299 Monoclonal / Vio Bright FITC / REA587