CD35 / PE-Cy7 / HB-8592
CD35 / PE-Cy7 / HB-8592
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab00897-10.3-pe/cy7 (View supplier product page) | |
| Size | 200 μg | |
| Price | ||
| Antigen | CD35 | |
| Clone | HB-8592 | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | PE-Cy7 | |
| Target Species | Baboon, Chimpanzee, Cynomolgus macaque, Human, Mouse, Rhesus macaque | |
| Applications | Immunoassay, FC, IF, ELISA, In Vivo | |
| Description | Anti-CD35 [HB-8592] |
About CD35 and PE-Cy7
| CD35 | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] | |
|---|---|---|
| PE-Cy7 | PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek). |
Citations
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