RAE-1 alpha/beta/gamma Monoclonal / APC-Vio770 / REA578

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-109-014 (View supplier product page)
Size 30 μg in 1 ml
Price $147.00
Antigen RAE-1 alpha/beta/gamma
Clone REA578
Host Cell Line
Isotype IgG1
Conjugate APC-Vio770
Target Species Mouse
Applications FC
Description Clone REA578 recognizes the Rae-1alpha/beta/gamma antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1alpha/beta/gamma were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells in vivo. Clone REA578 does not detect Rae-1delta/epsilon. | Additional information: Clone REA578 displays negligible binding to Fc receptors.
Citations
PMID 8982867
PMID 11248803
PMID 11557981
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APC-Vio770 Excitation and Emission Spectra