CD66 / PE-Cy7 / Arcitumomab
CD66 / PE-Cy7 / Arcitumomab
Product Details
| Supplier | Absolute Antibody | |
|---|---|---|
| Catalog #: | Ab00281-1.6-pe/cy7 (View supplier product page) | |
| Size | 200 μg | |
| Price | ||
| Antigen | CD66 | |
| Clone | Arcitumomab | |
| Host | Mouse | |
| Isotype | Fab Fragment | |
| Conjugate | PE-Cy7 | |
| Target Species | Human | |
| Applications | Bioimaging, FC, IHC-P | |
| Description | Anti-carcinoembryonic antigen (CEA) [Arcitumomab] |
About CD66 and PE-Cy7
| CD66 | This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010] | |
|---|---|---|
| PE-Cy7 | PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek). |
Citations
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