Catenin p120 (pS288) Monoclonal / PE / REA498

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-108-794 (View supplier product page)
Size 30 tests in 300 µL
Price $110.00
Antigen Catenin p120 (pS288)
Clone REA498
Host Human
Isotype IgG1
Conjugate PE
Target Species Human
Applications FC
Description Clone REA498 recognizes the human p120 catenin antigen phosphorylated at serine 288 (pS288). p120 catenin exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. p120 catenin is a prototypic member of subfamily of armadillo-domain (ARM) proteins. The p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localized at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Phosphorylation of p120 catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases. | Additional information: Clone REA498 displays negligible binding to Fc receptors.
Citations
PMID 16904204
PMID 22513089
PMID 25386896
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PE Excitation and Emission Spectra