CD140a Monoclonal / Vio Bright FITC / APA5

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-108-746 (View supplier product page)
Size 9 μg in 300 μl
Price $81.00
Antigen CD140a
Clone APA5
Host Rat
Isotype IgG2a κ
Conjugate Vio Bright FITC
Target Species Mouse
Applications FC
Description Clone APA5 reacts with the transmembrane glycoprotein CD140a, the α chain of the platelet-derived growth factor receptor (PDGFR). The two isoforms of the receptor can form homodimers (α/α or β/β) or α/β heterodimers. Receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140a is broadly expressed in embryonic tissue, mostly in cells of mesodermal origin in adult tissue, and embryonic stem cell–derived cardiomyogenic cells. Expression of CD140a is associated with various malignancies.
About CD140a and Vio Bright FITC
CD140a This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Vio Bright FITC Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Vio Bright FITC Excitation and Emission Spectra