FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-108-396 (View supplier product page)
	Size	9 μg in 30 μl
	Price	$60.00
	Antigen	CCR6
	Clone	REA277
	Host	Human
	Isotype	IgG1
	Conjugate	PE-Vio615
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA277 recognizes the CD196 antigen, a G protein–linked chemokine receptor also known as C-C chemokine receptor type 6 (CCR6). CD196 is preferentially expressed by B cells, immature dendritic cells, and subsets of T cells. The ligand of CD196 is macrophage inflammatory protein 3 alpha (MIP-3α) and binding subsequently transduces a signal by increasing the intracellular calcium ions level. CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Targeting CD196 or its ligand may be a promising therapeutic strategy to alleviate atherosclerosis. \| Additional information: Clone REA277 displays negligible binding to Fc receptors. \|

	CCR6	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
	PE-Vio615	PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594

$60.00
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CCR6 Monoclonal / PE-Vio615 / REA277