CD65 Monoclonal / PE / VIM8

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-108-236 (View supplier product page)
Size 100 Tests in 1 ml
Price $310.00
Antigen CD65
Clone VIM8
Host Mouse
Isotype IgM
Conjugate PE
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone VIM8 recognizes the human CD65 antigen, a fucosylated carbohydrate on the cell surface, which is also known as ceramide dodecasaccharide or VIM-2. CD65 is formed by fucosylation of the inner lactosamine unit of α-2,3-sialylated polylactosamine by α-1,3-fucosyltransferase. It is expressed on all myeloid cells during development, highly on granulocytes and weakly on monocytes in peripheral blood. The sialylated form of CD65 (designated CD65s) appears when the progenitor antigen CD34 disappears, suggesting that this sialylated carbohydrate antigen marks a turning point in normal myeloid differentiation. CD65 is a critical adhesion molecule for extravascular acute myeloid leukemia cell infiltration. |
Citations
PMID 1349618
PMID 7683483
PMID 8830039
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PE Excitation and Emission Spectra