FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-107-799 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$360.00
	Antigen	CD302
	Clone	REA509
	Host	Human
	Isotype	IgG1
	Conjugate	APC-Vio770
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA509 recognizes the human CD302 antigen, a single-pass type I membrane protein, which is also known as C-type lectin domain family 13 member A (CLEC13A) or DCL-1. The C-type lectin superfamily is a large group of proteins which are characterized by the presence of one or more C-type lectin-like domains (CTLDs). The superfamily is divided into 17 groups based on their phylogeny and domain organisation. Despite the presence of a highly conserved domain, C-type lectins are functionally diverse and have been implicated in various processes including cell adhesion, tissue integration and remodelling, platelet activation, complement activation, pathogen recognition, endocytosis, and phagocytosis. CD302 was identified as a genetic fusion partner of human CD205 (DEC-205) in Hodgkin's lymphoma cell lines and is classified as a group XV C-type lectin. The receptor consists of a single extracellular CTLD, a short spacer followed by a transmembrane region, and a cytoplasmic tail containing a putative tyrosine-based internalisation motif. Human CD302 is expressed on monocytes, macrophages, granulocytes, and dendritic cells. \| Additional information: Clone REA509 displays negligible binding to Fc receptors.

	CD302	CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]
	APC-Vio770	APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

$360.00
Supplier Page

CD302 Monoclonal / APC-Vio770 / REA509