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	Supplier	Miltenyi Biotec
	Catalog #:	130-107-587 (View supplier product page)
	Size	30 μg in 1 ml
	Price	$53.00
	Antigen	CD49a
	Clone	REA493
	Host	Cell Line
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Mouse, Rat
	Applications	FC
	Description	Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin alpha1 (Itga1). CD49a binds to CD29 (integrin beta1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-gamma production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation. \| Additional information: Clone REA493 displays negligible binding to Fc receptors.

	CD49a	This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

$53.00
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CD49a Monoclonal / Biotin / REA493