Histone H2A.X (pS139) Monoclonal / PE / REA502

Citations: (2)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-107-585 (View supplier product page)
Size 100 Tests
Price $274.00
Antigen Histone H2A.X (pS139)
Clone REA502
Host cell line
Isotype IgG1
Conjugate PE
Target Species Human, Mouse
Applications FC
Description Clone REA502 recognizes the human and mouse histone H2AX antigen phosphorylated at serine 139 (pS139). H2AX is a 14 kDa basal histone and a variant of the H2 histone family. It replaces conventional H2A in a subset of nucleosomes. When cells are exposed to ionizing radiation or DNA-damaging chemotherapeutic agents, double-stranded breaks (DSBs) are generated that rapidly result in the phosphorylation of H2AX at serine 139 (γH2AX). Because phosphorylation of H2AX is abundant, fast, and correlates well with each DSB, it is the most sensitive marker that can be used to examine the DNA damage produced and the subsequent repair of the DNA lesion. γH2AX also participates in the evolutionarily conserved process of sister chromatid recombination, a homologous recombination pathway involved in the suppression of genomic instability during DNA replication and directly implicated in tumor suppression. | Additional information: Clone REA502 displays negligible binding to Fc receptors.
Citations
PMID 2587254
PMID 10959836
PMID 22941631
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PE Excitation and Emission Spectra