FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-107-044 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$265.00
	Antigen	CD132
	Clone	REA313
	Host	Human
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Human
	Applications	FC
	Description	Clone REA313 recognizes the human CD132 antigen, a 65–70 kDa single-pass type I membrane protein also known as common γ chain, which is shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. CD132 is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. The most common form of severe combined immune deficiency in humans, with lack of circulating T cells, a normal or increased number of B lymphocytes, and an X-linked pattern of inheritance (XSCID) has been shown to be due to defects of the CD132 gene. \| Additional information: Clone REA313 displays negligible binding to Fc receptors.

	CD132	The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

$265.00
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CD132 Monoclonal / Biotin / REA313