CD117 / PE-Dazzle 594 / ACK2
CD117 / PE-Dazzle 594 / ACK2
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 135127 (View supplier product page) | |
| Size | 25 μg | |
| Price | $141.00 | |
| Antigen | CD117 | |
| Clone | ACK2 | |
| Host | Rat | |
| Isotype | IgG2b κ | |
| Conjugate | PE-Dazzle 594 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | PE/Dazzle 594 anti-mouse CD117 (c-kit) |
About CD117 and PE-Dazzle 594
| CD117 | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] | |
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| PE-Dazzle 594 | PE-Dazzle® 594 (RPE-Dazzle 594) from Biolegend is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Dazzle 594. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Dazzle 594, which emitts light that can be captured with a 610/20 nm bandpass filter. PE-Dazzle 594 has an excitation peak at 565 nm and an emission peak at 610 nm, and is suitable alternative to PE-Texas Red, PE-eF610, PE-Alexa Fluor™ 610 or PE-CF®594. |
Images
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C57BL/6 bone marrow cells were stained with CD11b APC and CD117 (clone ACK2) PE/Dazzle™ 594 (top) or rat IgG2b, κ PE/Dazzle™ 594 isotype control (bottom). |
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Citations
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Reviews & Ratings
PE-Dazzle 594 Excitation and Emission Spectra
$141.00
Supplier Page
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