FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab02472-1.1-atto488 (View supplier product page)
	Size	200 μg
	Price
	Antigen	ErbB3
	Clone	AB#3
	Host	Mouse
	Isotype	IgG1
	Conjugate	ATTO 488
	Target Species	Human
	Applications	Surface Plasmon Resonance, ELISA, Functional
	Description	Anti-HER3 [AB#3]

	ErbB3	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
	ATTO 488	ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.

	Additional Sources

ErbB3 / ATTO 488 / AB#3