CD62L / redFluor 710 / MEL-14

Product Details
Supplier Tonbo (OWL)
Catalog #: 80-0621_OWL (View supplier product page)
Size 25 μg
Price $86.00
Antigen CD62L
Clone MEL-14
Host Rat
Isotype IgG2a κ
Conjugate redFluor 710
Target Species Mouse
Applications FC
Description The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte "rolling" on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.
About CD62L and redFluor 710
CD62L This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
redFluor 710 redFluor 710 is a fluorophore with an excitation peak at 700 nm and an emission peak at 710 nm. It can be used with the following analysis platforms: Flow Cytometry.
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redFluor 710 Excitation and Emission Spectra