CD45 / redFluor 710 / HI30

Product Details
Supplier Tonbo (OWL)
Catalog #: 80-0459_OWL (View supplier product page)
Size 25 Tests
Price $23.00
Antigen CD45
Clone HI30
Host Mouse
Isotype IgG1 κ
Conjugate redFluor 710
Target Species Human
Applications FC
Description The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.The HI30 antibody is widely used as a marker for human CD45 expression on T cells, B cells, monocytes, macrophages, and NK cells. -
About CD45 and redFluor 710
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
redFluor 710 redFluor 710 is a fluorophore with an excitation peak at 700 nm and an emission peak at 710 nm. It can be used with the following analysis platforms: Flow Cytometry.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

redFluor 710 Excitation and Emission Spectra