Ly-6G / Biotin / RB6-8C5
Ly-6G / Biotin / RB6-8C5
Product Details
Supplier | Tonbo (OWL) | |
---|---|---|
Catalog #: | 30-5931_OWL (View supplier product page) | |
Size | 25 μg | |
Price | $20.00 | |
Antigen | Ly-6G | |
Clone | RB6-8C5 | |
Host | Rat | |
Isotype | IgG2b κ | |
Conjugate | Biotin | |
Target Species | Mouse | |
Applications | FC | |
Description | The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils. In the mouse, the RB6-8C5 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes.Note: The RB6-8C5 antibody has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151:2399-2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111-123) and has been cited in the literature for identification of Ly-6G/Ly-6C. Other reports suggest that this antibody is specific for Ly-6G, without cross-reactivity for Ly-6C (Nagendra S. and Schlueter AJ. 2003. Cytometry A, 58(2): 195-200. |
About Ly-6G and Biotin
Ly-6G | LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009] |
---|
Citations
Reviews & Ratings
Biotin Excitation and Emission Spectra
$20.00
Supplier Page
Supplier Page