FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab02370-23.0-ap (View supplier product page)
	Size	200 μg
	Price
	Antigen	Ig Lambda Light Chain
	Clone	4-D11
	Host	Rabbit
	Isotype	IgG
	Conjugate	Alk Phosphatase
	Target Species	Ferret
	Applications	ELISA, WB, FC
	Description	Anti-lambda light chain [4-D11]

	Ig Lambda Light Chain	Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]

	Additional Sources

Ig Lambda Light Chain / Alk Phosphatase / 4-D11