FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab00743-2.0-ap (View supplier product page)
	Size	200 μg
	Price
	Antigen	CD40
	Clone	A54 scFv
	Host	Mouse
	Isotype	IgG2a
	Conjugate	Alk Phosphatase
	Target Species	Human
	Applications	ELISA, Block/Neutralize, Activation
	Description	Anti-CD40 [A54 scFv]

	CD40	This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

	Additional Sources

CD40 / Alk Phosphatase / A54 scFv