FluoroFinder

	Supplier	Absolute Antibody
	Catalog #:	Ab01577-23.0-ap (View supplier product page)
	Size	200 μg
	Price
	Antigen	CCR5
	Clone	T21/8
	Host	Rabbit
	Isotype	IgG
	Conjugate	Alk Phosphatase
	Target Species	Human
	Applications	WB, IF, FC, ELISA, IP
	Description	Anti-CCR5 [T21/8]

	CCR5	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

	Additional Sources

CCR5 / Alk Phosphatase / T21/8