CD45 / PerCP-Cy5.5 / 2D1
CD45 / PerCP-Cy5.5 / 2D1
Citations:
(11)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 368503 (View supplier product page) | |
| Size | 25T | |
| Price | $147.00 | |
| Antigen | CD45 | |
| Clone | 2D1 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | PerCP-Cy5.5 | |
| Target Species | Human | |
| Applications | FC | |
| Description | PerCP/Cyanine5.5 anti-human CD45 |
About CD45 and PerCP-Cy5.5
| CD45 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] | |
|---|---|---|
| PerCP-Cy5.5 | PerCP-Cyanine® 5.5 (PerCP-Cy5.5) is a red-emitting tandem fluorophore that was originally designed to make the PerCP fluorophore more stable and increase signal intensity. The donor molecule, PerCP can be excited by the 488-nm blue laser and and transfers energy to the acceptor molecule, Cy5.5, which emitts light that can be captured with a 695/40 nm bandpass filter. PerCP-Cy5.5 has an excitation peak at 482 nm and an emission peak at 695 nm. There are superior alternatives to PerCP and PerCP-Cy5.5 including RealBlue 705 (BD Biosciences), NovaFluor Blue 690 or PerCP-eFluor™ 710. |
Images
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Human peripheral blood lymphocytes were stained with CD45 (clone 2D1) PerCP/Cyanine5.5 (filled histogram), or mouse IgG1, κ PerCP/Cyanine5.5 isotype control (open histogram). |
Citations
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Reviews & Ratings
PerCP-Cy5.5 Excitation and Emission Spectra
$147.00
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