ChT1 / Biotin / CT1

Product Details
Supplier Abcam
Catalog #: ab25168 (View supplier product page)
Size 250 μg
Price $370.00
Antigen ChT1
Clone CT1
Host Mouse
Isotype IgG1
Conjugate Biotin
Target Species Avian, Chicken
Applications FC, Functional
Description Monoclonal
About ChT1 and Biotin
ChT1 This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
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Biotin Excitation and Emission Spectra