Wilm's Tumor 1 / DyLight 488 / WT1/1434R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-11622G (View supplier product page)
Size 100 μl
Price $649.00
Antigen Wilm's Tumor 1
Clone WT1/1434R
Host Rabbit
Isotype IgG
Conjugate DyLight 488
Target Species Human
Applications IHC, IHC-P
Description WT1 Antibody (WT1/1434R) [DyLight 488]
About Wilm's Tumor 1 and DyLight 488
Wilm's Tumor 1 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra