Wilm's Tumor 1 / Janelia Fluor 646 / SPM361

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-11553JF646 (View supplier product page)
Size 100 μl
Price $649.00
Antigen Wilm's Tumor 1
Clone SPM361
Host Mouse
Isotype IgG1 κ
Conjugate Janelia Fluor 646
Target Species Human, Rat
Applications IHC, IHC-P
Description WT1 Antibody (SPM361) [Janelia Fluor® 646]
About Wilm's Tumor 1 and Janelia Fluor 646
Wilm's Tumor 1 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra