CD162 / Biotin / PSGL1/8135R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-20931B (View supplier product page)
Size 100 μl
Price $629.00
Antigen CD162
Clone PSGL1/8135R
Host Rabbit
Isotype IgG κ
Conjugate Biotin
Target Species Human
Applications IHC-P
Description PSGL-1/CD162 Antibody (PSGL1/8135R) [Biotin]
About CD162 and Biotin
CD162 This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
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Biotin Excitation and Emission Spectra