PRDM9 / DyLight 405 / RAB-C370

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-20141V (View supplier product page)
Size 100 μl
Price $419.00
Antigen PRDM9
Clone RAB-C370
Host Rabbit
Isotype IgG κ
Conjugate DyLight 405
Target Species Human
Applications FC, ELISA, ICC, IF, IP, Mass Spectrometry, ChIP
Description PRDM9 Antibody (RAB-C370) [DyLight 405] - Chimeric
About PRDM9 and DyLight 405
PRDM9 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra