PRDM9 / Alexa Fluor 647 / RAB-C370

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-20141AF647 (View supplier product page)
Size 100 μl
Price $419.00
Antigen PRDM9
Clone RAB-C370
Host Rabbit
Isotype IgG κ
Conjugate Alexa Fluor 647
Target Species Human
Applications FC, ELISA, ICC, IF, IP, Mass Spectrometry, ChIP
Description PRDM9 Antibody (RAB-C370) [Alexa Fluor® 647] - Chimeric
About PRDM9 and Alexa Fluor 647
PRDM9 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra