Perforin / Janelia Fluor 646 / PRF1/8662R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-21083JF646 (View supplier product page)
Size 100 μl
Price $689.00
Antigen Perforin
Clone PRF1/8662R
Host Rabbit
Isotype IgG κ
Conjugate Janelia Fluor 646
Target Species Human
Applications IHC-P
Description Perforin Antibody (PRF1/8662R) [Janelia Fluor® 646]
About Perforin and Janelia Fluor 646
Perforin This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra