Perforin / Alexa Fluor 405 / PRF1/8662R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-21083AF405 (View supplier product page)
Size 100 μl
Price $689.00
Antigen Perforin
Clone PRF1/8662R
Host Rabbit
Isotype IgG κ
Conjugate Alexa Fluor 405
Target Species Human
Applications IHC-P
Description Perforin Antibody (PRF1/8662R) [Alexa Fluor® 405]
About Perforin and Alexa Fluor 405
Perforin This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra