MDM4 / DyLight 405 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-556V (View supplier product page)
Size 100 μl
Price $549.00
Antigen MDM4
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 405
Target Species Human
Applications WB, IP, Knockout Validated
Description MDMX Antibody [DyLight 405]
About MDM4 and DyLight 405
MDM4 This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra