Glypican 3 / Janelia Fluor 646 / GPC3/8148R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-21040JF646 (View supplier product page)
Size 100 μl
Price $629.00
Antigen Glypican 3
Clone GPC3/8148R
Host Rabbit
Isotype IgG κ
Conjugate Janelia Fluor 646
Target Species Human
Applications IHC-P
Description Glypican 3 Antibody (GPC3/8148R) [Janelia Fluor® 646]
About Glypican 3 and Janelia Fluor 646
Glypican 3 Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra