ErbB2 / Alexa Fluor 700 / rERBB2/9401

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-24036AF700 (View supplier product page)
Size 100 μl
Price $599.00
Antigen ErbB2
Clone rERBB2/9401
Host Mouse
Isotype IgG2b κ
Conjugate Alexa Fluor 700
Target Species Human
Applications IHC-P
Description ErbB2/Her2 Antibody (rERBB2/9401) [Alexa Fluor® 700]
About ErbB2 and Alexa Fluor 700
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Alexa Fluor 700 Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720.
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Alexa Fluor 700 Excitation and Emission Spectra