Estrogen Receptor alpha / Alexa Fluor 405 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB200-347AF405 (View supplier product page)
Size 100 μl
Price $549.00
Antigen Estrogen Receptor alpha
Clone
Host Rabbit
Isotype IgG
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, IP
Description ER alpha/NR3A1 Antibody [Alexa Fluor® 405]
About Estrogen Receptor alpha and Alexa Fluor 405
Estrogen Receptor alpha This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra